Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC075
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-29 15:56
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment NEW PATIENT

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 40, 'TN': 28, 'TP': 2, 'FP': 2}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 16, 'TN': 11, 'TP': 26, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 28, 'TN': 23, 'TP': 14, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 34, 'TN': 25, 'TP': 8, 'FP': 5}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.268
timePerCircleCoV 0.0990661
timePerCircleSlope 0.0016344
meanError 2.55805
tremorFreq 6.73828
tremorRelPower 47.9573
tremorGyroAmpMean 0.0938323
tremorGyroAmpSlope -0.00617641
tremorGyroAmpCoV 0.436324
tremorCoordAmpMean 0.118321
tremorCoordAmpSlope -0.00983472
tremorCoordAmpCoV 0.385376
tremorAccAmpMean 0.116496
tremorAccAmpSlope -0.0105499
tremorAccAmpCoV 0.413645
tremorPcRelVar 0.701439
tremorPcX 0.598298
tremorPcY -0.801273

Circle Segment 1

Duration 6.76 s, Accuracy Estimate 2.488 (lower is better)

Circle Segment 2

Duration 8.48 s, Accuracy Estimate 3.539 (lower is better)

Circle Segment 3

Duration 6.8 s, Accuracy Estimate 3.628 (lower is better)

Circle Segment 4

Duration 7.32 s, Accuracy Estimate 3.008 (lower is better)

Circle Segment 5

Duration 6.48 s, Accuracy Estimate 2.597 (lower is better)

Circle Segment 6

Duration 6.52 s, Accuracy Estimate 2.572 (lower is better)

Circle Segment 7

Duration 8.04 s, Accuracy Estimate 1.638 (lower is better)

Circle Segment 8

Duration 7.68 s, Accuracy Estimate 1.693 (lower is better)

Circle Segment 9

Duration 7.92 s, Accuracy Estimate 1.717 (lower is better)

Circle Segment 10

Duration 6.68 s, Accuracy Estimate 2.702 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 24.448
timePerSpiralCoV 0.135424
timePerSpiralSlope 0.0225686
meanError 1.64074
tremorFreq 6.64062
tremorRelPower 50.7993
tremorGyroAmpMean 0.109545
tremorGyroAmpSlope 0.000826
tremorGyroAmpCoV 0.467781
tremorCoordAmpMean 0.120087
tremorCoordAmpSlope 0.000852042
tremorCoordAmpCoV 0.428454
tremorAccAmpMean 0.101473
tremorAccAmpSlope 0.000244947
tremorAccAmpCoV 0.397151
tremorPcRelVar 0.753887
tremorPcX -0.816529
tremorPcY 0.577305

Spiral Segment 1

Duration 26.96 s, Accuracy Estimate 1.623 (lower is better)

Spiral Segment 2

Duration 20.4 s, Accuracy Estimate 1.994 (lower is better)

Spiral Segment 3

Duration 21.88 s, Accuracy Estimate 1.65 (lower is better)

Spiral Segment 4

Duration 24.84 s, Accuracy Estimate 1.76 (lower is better)

Spiral Segment 5

Duration 22.24 s, Accuracy Estimate 1.554 (lower is better)

Spiral Segment 6

Duration 20.36 s, Accuracy Estimate 1.612 (lower is better)

Spiral Segment 7

Duration 25.88 s, Accuracy Estimate 1.74 (lower is better)

Spiral Segment 8

Duration 23.56 s, Accuracy Estimate 1.746 (lower is better)

Spiral Segment 9

Duration 29.2 s, Accuracy Estimate 1.305 (lower is better)

Spiral Segment 10

Duration 29.16 s, Accuracy Estimate 1.425 (lower is better)

Elel

eDurationMean 0.490517
eDurationStd 0.202407
eDurationStdnorm 0.412639
eDurationMedian 0.42
eDurationQuartdelta 0.21625
eDurationQuartdeltanorm 0.514881
eDurationKurt 5.25879
eDurationTrenddiff -0.1975
eDurationTrendratio 0.644144
eWidthMean 3.02183
eWidthStd 0.959761
eWidthStdnorm 0.31761
eWidthMedian 2.925
eWidthQuartdelta 1.31625
eWidthQuartdeltanorm 0.45
eWidthKurt 3.93914
eWidthTrenddiff -0.6435
eWidthTrendratio 0.784314
eHeightMean 3.68752
eHeightStd 1.94692
eHeightStdnorm 0.527976
eHeightMedian 2.925
eHeightQuartdelta 1.404
eHeightQuartdeltanorm 0.48
eHeightKurt 4.37763
eHeightTrenddiff -0.8775
eHeightTrendratio 0.741379
eAspectMean 0.895682
eAspectStd 0.235173
eAspectStdnorm 0.262563
eAspectMedian 0.888889
eAspectQuartdelta 0.304754
eAspectQuartdeltanorm 0.342849
eAspectKurt 5.01852
eAspectTrenddiff 0.0562042
eAspectTrendratio 1.06623
eSlantMean -0.330947
eSlantStd 0.393486
eSlantStdnorm -1.18897
eSlantMedian -0.384615
eSlantQuartdelta 0.534211
eSlantQuartdeltanorm -1.38895
eSlantKurt 2.47331
eSlantTrenddiff -0.321868
eRtopMean 0.40876
eRtopStd 0.226936
eRtopStdnorm 0.555182
eRtopMedian 0.4
eRtopQuartdelta 0.304705
eRtopQuartdeltanorm 0.761762
eRtopKurt 2.35277
eRtopTrenddiff -0.150107
eRbotMean 0.753493
eRbotStd 0.328002
eRbotStdnorm 0.435309
eRbotMedian 0.736842
eRbotQuartdelta 0.534948
eRbotQuartdeltanorm 0.726002
eRbotKurt 2.03096
eRbotTrenddiff -0.04955
eRrightMean 0.512259
eRrightStd 0.235602
eRrightStdnorm 0.459928
eRrightMedian 0.555556
eRrightQuartdelta 0.319177
eRrightQuartdeltanorm 0.574519
eRrightKurt 2.56954
eRrightTrenddiff 0.104786
eRleftMean 0.555342
eRleftStd 0.226406
eRleftStdnorm 0.407687
eRleftMedian 0.55
eRleftQuartdelta 0.285681
eRleftQuartdeltanorm 0.51942
eRleftKurt 2.30708
eRleftTrenddiff -0.109435
lDurationMean 0.784184
lDurationStd 0.236543
lDurationStdnorm 0.301642
lDurationMedian 0.69
lDurationQuartdelta 0.28625
lDurationQuartdeltanorm 0.414855
lDurationKurt 4.99868
lDurationTrenddiff -0.2775
lDurationTrendratio 0.697548
lWidthMean 4.6012
lWidthStd 1.30053
lWidthStdnorm 0.28265
lWidthMedian 4.329
lWidthQuartdelta 1.19925
lWidthQuartdeltanorm 0.277027
lWidthKurt 5.14769
lWidthTrenddiff -0.819
lWidthTrendratio 0.831325
lHeightMean 10.9335
lHeightStd 3.89168
lHeightStdnorm 0.35594
lHeightMedian 9.36
lHeightQuartdelta 5.2065
lHeightQuartdeltanorm 0.55625
lHeightKurt 3.2847
lHeightTrenddiff -5.2065
lHeightTrendratio 0.609649
lAspectMean 0.444907
lAspectStd 0.110483
lAspectStdnorm 0.248327
lAspectMedian 0.435897
lAspectQuartdelta 0.136774
lAspectQuartdeltanorm 0.313775
lAspectKurt 3.52711
lAspectTrenddiff 0.0977411
lAspectTrendratio 1.24496
lSlantMean 0.0751063
lSlantStd 0.118311
lSlantStdnorm 1.57524
lSlantMedian 0.0533333
lSlantQuartdelta 0.15493
lSlantQuartdeltanorm 2.90493
lSlantKurt 3.04078
lSlantTrenddiff 0.0082133
lRtopMean 0.715497
lRtopStd 0.113206
lRtopStdnorm 0.15822
lRtopMedian 0.727273
lRtopQuartdelta 0.134728
lRtopQuartdeltanorm 0.185251
lRtopKurt 3.35667
lRtopTrenddiff -0.00879943
lRbotMean 0.565057
lRbotStd 0.197879
lRbotStdnorm 0.350193
lRbotMedian 0.571429
lRbotQuartdelta 0.269686
lRbotQuartdeltanorm 0.47195
lRbotKurt 3.64876
lRbotTrenddiff -0.0205471
lRrightMean 0.85976
lRrightStd 0.0720763
lRrightStdnorm 0.083833
lRrightMedian 0.8625
lRrightQuartdelta 0.0854197
lRrightQuartdeltanorm 0.0990373
lRrightKurt 2.88444
lRrightTrenddiff -0.0459791
lRleftMean 0.261486
lRleftStd 0.0973057
lRleftStdnorm 0.372126
lRleftMedian 0.253425
lRleftQuartdelta 0.12634
lRleftQuartdeltanorm 0.498529
lRleftKurt 3.21594
lRleftTrenddiff -0.022744

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.609674
sumTouchScores 29.2644
meanMovementTime 0.391915
numTouches 48
undershootPercentage 18.75
overshootPercentage 18.75

FITTS Long Modified

meanTouchScore 0.671523
sumTouchScores 16.1166
meanMovementTime 0.801087
numTouches 24
undershootPercentage 4.16667
overshootPercentage 29.1667

ZigZag

numZigzags 4
timePerZigzagMean 26.1
timePerZigzagCoV 0.216541
timePerZigzagSlope 0.10023
meanError 2.47414
tremorFreq 6.44531
tremorRelPower 51.402
tremorGyroAmpMean 0.272307
tremorGyroAmpSlope -0.00436282
tremorGyroAmpCoV 0.362681
tremorCoordAmpMean 0.288032
tremorCoordAmpSlope -0.00635477
tremorCoordAmpCoV 0.449295
tremorAccAmpMean 0.266171
tremorAccAmpSlope -0.00610546
tremorAccAmpCoV 0.451666
tremorPcRelVar 0.791761
tremorPcX -0.947397
tremorPcY -0.32006

ZigZag Segment 1

Duration 18.08 s, Accuracy Estimate 3.012 (lower is better)

ZigZag Segment 2

Duration 29.28 s, Accuracy Estimate 2.454 (lower is better)

ZigZag Segment 3

Duration 30.72 s, Accuracy Estimate 2.106 (lower is better)

ZigZag Segment 4

Duration 26.32 s, Accuracy Estimate 2.325 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 17.144
timePerZigzagCoV 0.214542
timePerZigzagSlope -0.119225
zigzagHeightMean 76.5393
zigzagHeightCoV 0.0228757
zigzagHeightSlope 0.00730939
meanError 0.0406423
tremorFreq 6.44531
tremorRelPower 41.7375
tremorGyroAmpMean 0.16445
tremorGyroAmpSlope -0.0053838
tremorGyroAmpCoV 0.441754
tremorCoordAmpMean 0.196043
tremorCoordAmpSlope -0.00459187
tremorCoordAmpCoV 0.378212
tremorAccAmpMean 0.170471
tremorAccAmpSlope -0.00592877
tremorAccAmpCoV 0.384492
tremorPcRelVar 0.712691
tremorPcX 0.939983
tremorPcY 0.341221

ZigZag Offset Segment 1

Duration 23.44 s, Accuracy Estimate 0.074 (lower is better)

ZigZag Offset Segment 2

Duration 16.8 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 3

Duration 16.2 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 4

Duration 15.32 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 13.96 s, Accuracy Estimate 0.049 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.74}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.799986359206942}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8478728026724558}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}